PYRIMIDYL-5-BORONIC ACID PINACOLATE

PYRIMIDYL-5-BORONIC ACID PINACOLATE - Names and Identifiers

Name	Pyrimidine-5-boronic acid pinacol ester
Synonyms	PYRIMIDYL-5-BORONIC ACID PINACOLATE PYRIMIDINE-5-BORONIC ACID PINACOLATE PYRIMIDYL-5-BORONIC ACID PINACOL ESTER PYRIMIDINE-5-BORONIC ACID PINACOL ESTER Pyrimidine-5-boronic acid pinacol ester PYRIMIDIN-5-YLBORONIC ACID PINACOL ESTER Pinacol Ester Pyrimidinyl-5-Boronic Acid PINACOL ESTER PYRIMIDINYL-5-BORONIC ACID 5-Pyrimidineboronic acid pinacol ester 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine PyriMidine,5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)- Pyrimidine, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
CAS	321724-19-0
InChI	InChI=1/C10H15BN2O2/c1-9(2)10(3,4)15-11(14-9)8-5-12-7-13-6-8/h5-7H,1-4H3

PYRIMIDYL-5-BORONIC ACID PINACOLATE - Physico-chemical Properties

Molecular Formula	C10H15BN2O2
Molar Mass	206.05
Density	1.07±0.1 g/cm3(Predicted)
Melting Point	60-66°C
Boling Point	308.9±15.0 °C(Predicted)
Flash Point	140.6°C
Vapor Presure	0.0012mmHg at 25°C
pKa	1.63±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.488
MDL	MFCD05155223

PYRIMIDYL-5-BORONIC ACID PINACOLATE - Risk and Safety

Hazard Symbols	Xi - Irritant
Hazard Class	IRRITANT

PYRIMIDYL-5-BORONIC ACID PINACOLATE - Reference Information

Use

Pyrimidine -5-boric acid taenol ester is used to prepare indole derivatives and has a wide range of pharmacological activities as a selective Pim kinase inhibitor. It is also used to prepare TGF-β1 inhibitor and activin A signal transduction, and is an important chemical product and key pharmaceutical and chemical intermediate products.

preparation

borate ester was synthesized from pyrimidine chloride under Pd catalytic system with B 2 (pin) 2 as boron reagent at room temperature. the specific synthesis route is shown in the figure below. Fig. 1 synthesis roadmap of pyrimidine -5-boric acid cynolol ester shows that pyrimidine -5-boric acid cynolol ester is prepared by reacting pyrimidine-based chlorides for 1 h at room temperature with B 2 (pin) 2 as boron reagent, potassium phosphate 7 hydrate as alkali and ethanol as solvent under 0. 5 mol% Xphos-Pd-G2 and 0. 25 mol% Xphos catalytic system.

Last Update：2024-04-09 21:01:54

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